3月9日晚在洛杉矶举行的Paley Festival 上，PB的主创人员宣布第三季仍然会在达拉斯拍摄，但是同时也会在佛罗里达和路易斯安娜取一部分景。
The show will continue to shoot in Dallas for season three, with secondary units covering Florida and Lousiana.
Season 3 of Prison Break (which may have a different name announced soon)
will be premiered on 29th August 2007, almost 5 months after the season
该剧的创作者和执行导演Paul Scheuring 说：“第三季本质上是新的一章，它将回到本剧所要表达的本意（即越狱）。”
但是据Scheuring 说当linc和michael在第三季回归时不要指望他们俩都还是安全的，Scheuring 暗示了他俩中的一个将在前半季中死掉。
Fox has picked up the action drama “Prison Break” for a third season.
Details on the serialized drama's story line for next season are being kept under wraps, but it is understood that brothers Michael (Wentworth Miller) and Lincoln (Dominic Purcell) — who recently escaped to Panama with the FBI hot on their trail — and many of their fellow fugitives would end up back behind bars, possibly in Panama.
“It essentially will be a new chapter,” creator/executive producer Paul Scheuring said. “It's going to return to the fundamental conceit, to the roots of what the show was about.”
In its first season, “Break” featured most characters locked in prison and planning an escape. The current second season chronicles the manhunt that ensued after the core group broke out.
“They got scattered in the winds — their stories became separate and defused,” Scheuring said. “They will come back together again, (and) their conflicts and interactions will return.”
The options on the “Break” actors are not due for a pickup until May, but it is understood that a significant number of the regulars this season will return in the fall. The show also will introduce many new characters, Scheuring said.
But while stars Miller and Purcell will return next season, don't consider them safe, Scheuring said, hinting that one of them might not survive beyond the first couple of episodes.
Scheuring already has begun scouting locations for Season 3. Production will be based in Dallas. There will be splinter units working in Florida, which has doubled for Panama this year, and Louisiana, also expected to double for Panama.
In its second season, “Break” has averaged 9.1 million viewers and a 3.7 rating/10 share among adults 18-49. The series ranks No. 1 in its 8 p.m. Monday period in adults 18-34 and No. 1 among adults 18-49.
“Break” is the third live-action series to receive an early pickup for next season, joining the dramas “House” and “Bones.”